Abstract: In the context of near-fault pulse-like ground motions, significant characteristics are often observed, including energy concentration, a prevalence of low-frequency components, and extended periods. These characteristics can have a substantial impact on the seismic response spectra. Therefore, in order to fully consider the influence of near-fault pulse-like ground motions on the design response spectra for seismic isolation structure （hereinafter referred to as the seismic isolation design spectra）, near-fault pulse-like ground motions are selected as the research object, and based on the relevant provisions on the seismic isolation design spectra in the Standard for Seismic Isolation Design of Buildings （GB/T 51408−2021）, the research on the seismic isolation design spectra of near-fault regions is carried out. For the purpose of this study, 140 sets of near-fault pulse-like ground motions were meticulously selected from the NGA-West2 database. The selection of these records was based on the criteria, which included a moment magnitude of ≥5.0 and a fault distance ≤40 km, and the velocity pulse identification method based on the wavelet transform was used in the selection process. Based on the seismic motions that have been selected, the seismic response spectra were computed with assurance rates of 50% （average spectrum） and 84% （average spectrum ＋ 1 standard deviation spectrum）, respectively. The actual near-fault seismic response spectra were calculated and then analyzed in comparison with the current seismic isolation design spectra. The results revealed that the current seismic isolation design spectra in China have not fully considered the characteristics of near-fault pulse-like ground motions. This is manifested in the lower spectral values of the current seismic isolation design spectra compared with those of the actual near-fault seismic response spectra in some periods, which may lead to insufficient redundancy for structures in the near-fault regions. In light of the analyses results, we propose a method for adjusting the seismic isolation design spectrum in the near fault regions. The proposed method aims to enhance the seismic safety of seismic isolation structures in this region by optimizing the amplitude enhancement coefficient, characteristic period, and attenuation index of the seismic isolation design spectra. This objective is pursued by retaining the three-stage formula specified in the current seismic isolation design spectra. Firstly, it is proposed to increase the amplitude enhancement coefficient to 1.35 to reflect the energy concentration effect of near-fault pulse-like ground motions, so as to enhance the seismic performance of the structures under seismic actions. Additionally, a recommendation is made to adjust the lower limit of the characteristic period corresponding to earthquakes of different fortification levels. The adjusted lower limits are as follows: 0.65 s for fortification earthquakes, 0.70 s for rare earthquakes, and 0.75 s for extremely rare earthquakes. These adjustments are intended to comprehensively consider the low-frequency characteristics of near-fault pulse-like ground motions and its substantial impact on structural response. Furthermore, it is recommended that the attenuation index of the descending section of the seismic isolation design spectrum curve be adjusted to 0.8. This adjustment would serve to more accurately reflect the characteristics of the seismic response in the long period section. Finally, the finding suggests that the values of other relevant parameters continue to adhere to the provisions stipulated in the current Standard for Seismic Isolation Design of Buildings, thereby ensuring the coordination and consistency of the aforementioned parameters. This modification method is useful, providing a reasonable reference for the seismic isolation design of structures in near-fault regions.